STRUCTURE OF ESCHERICHIA COLI RESPIRATORY COMPLEX I RECONSTITUTED INTO LIPID NANODISCS REVEALS AN UNCOUPLED CONFORMATION

Structure of Escherichia coli respiratory complex I reconstituted into lipid nanodiscs reveals an uncoupled conformation

Respiratory complex I is a multi-subunit membrane protein complex that reversibly couples NADH oxidation and ubiquinone reduction with proton translocation against transmembrane potential.Complex I from Escherichia coli is among the best functionally characterized complexes, but its structure remains unknown, girls shoes hindering further studies t

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Short-Term Effect of Continuous Subcutaneous Insulin Infusion and Multiple Daily Injection in Perioperative Patients with Type 2 Diabetes Mellitus

Background.Hyperglycemia is common and difficult to control in perioperative patients with type 2 diabetes mellitus (T2DM), which impacts their prognosis after operation.Our study investigated the short-term effect of continuous subcutaneous insulin infusion (CSII) and multiple daily injection (MDI) in perioperative SCALP TONIC T2DM patients using

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Lead/Drug Discovery from Natural Resources

Natural products and their derivatives have been shown to be effective drug candidates against various diseases for many years.Over a long period of time, nature has produced an abundant and prosperous source pool for novel therapeutic agents with distinctive structures.Major natural-product-based drugs approved for clinical use include anti-infect

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Alpha-fetoprotein, identified as a novel marker for the antioxidant effect of placental extract, exhibits synergistic antioxidant activity in the presence of estradiol.

Placenta, as a reservoir of nutrients, has been widely used in medical and cosmetic materials.Here, we focused on the antioxidant properties of placental extract and attempted to isolate and identify the main antioxidant factors.Porcine placental extracts were prepared through homogenization or acid hydrolysis, and their antioxidant activity was in

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